Thiamine transporter
Web13 Aug 2024 · In some tissues, thiamine uptake and secretion appears to be mediated by a soluble thiamine transporter that is dependent on Na + and a transcellular proton gradient. [8] Tissue distribution. Human storage of thiamine is about 25 to 30 mg, with the greatest concentrations in skeletal muscle, heart, brain, liver, and kidneys. ThMP and free ... Webspermine transporter* vacuolar membrane ROX1 Heme-dependent transcriptional repressor of hypoxic genes including CYC7 and ANB1 YPR065W The ROX1 gene encodes a heme-induced repressor of hypoxic genes in yeast. negative regulation of transcription from Pol II promoter DNA bending* nuclear chromosome BOP1
Thiamine transporter
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Web20 hours ago · Higher thiamine levels resulted in increased expression of thiamine transporter 1 and 2 both at mRNA and protein levels in human neck area-derived adipocytes. Gradually increasing concentrations of thiamine led to increased basal, cAMP-stimulated, and proton-leak respiration along with elevated mitochondrial biogenesis of the … WebThe results showed the expression of two thiamine transporter genes (SLC19A2, SLC25A19) as well as thiamine pyrophosphokinase-1 (TPK1) were decreased in both RNA and protein level in miR-155 dependent manner. Finally, we confirm the finding by showing a positive correlation between miR-155 and thiamine level in 71 triple negative breast tumors.
WebSLC19A2 and SLC19A3, also known as thiamine transporters (THTR) 1 and 2, respectively, transport the positively charged thiamine (vitamin B1) into cells to enable its efficient utilization. SLC19A2 and SLC19A3 are also known to transport structurally unrelated cationic drugs, such as metformin, but whether this charge selectivity extends to other … Web1 Jul 2003 · Therefore, thiamine transporter THTR2 gene expression is down-regulated in breast cancer, which may contribute to resistance to apoptosis in these tumors. Introduction Thiamine, like folate and other essential nutrients, uses specific carrier mechanisms for transport into cells.
WebBTRBGD is caused by mutations in the SLC19A3 gene on chromosome 2q36.6, encoding human thiamine transporter 2 (hTHTR2). Episodes of BTRBGD are often triggered by febrile illness. Case report The ... The thiamine transporter protein encoded by SLC19A2 has a 40% shared amino acid identity with the folate transporter SLC19A1. The N-terminal domain and the sequence between the C-terminal domain and sixth transmembrane domain are required for proper localization of this protein to the cell membrane. See more Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene. SLC19A2 is a thiamine transporter See more The SLC19A2 gene is located on the q arm of chromosome 1 in position 24.2 and spans 22,062 base pairs. The gene produces a 55.4 kDa … See more Mutations in the SLC19A2 gene can cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive … See more • Scharfe C, Hauschild M, Klopstock T, Janssen AJ, Heidemann PH, Meitinger T, Jaksch M (September 2000). "A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I". … See more The encoded protein is a high-affinity transporter specific to the intake of thiamine. Thiamine transport is not inhibited by other organic cations nor affected by sodium ion concentration; it is stimulated by a proton gradient directed outward, with an … See more This protein interacts with CERS2. See more • GeneReviews/NIH/NCBI/UW entry on Thiamine-Responsive Megaloblastic Anemia or Rogers Syndrome • See more
Web4 Mar 2013 · This gene controls the uptake of thiamine in the CNS via expression of the thiamine transporter protein THTR2. Dogs have two copies of this gene located within the candidate interval (SLC19A3.2 – 43.36–43.38 Mb and SLC19A3.1 – 43.411–43.419 Mb) on chromosome 25. Expression analysis in a normal dog revealed that one of the paralogs ... haveri karnataka 581110WebAlanine-serine-cysteine transporter-1 (ASC-1) and thiamine transporter 2 (ThTr2) for further investigation. ASC-1 mediates the transport of alanine, serine, cysteine, and glycine in a sodium independent manner. In the presence of ASC-1 selective inhibitor, the uptake of these amino acids during thermogenic stimulation was dampened in both types ... haveri to harapanahalliWeb11 Apr 2024 · Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent enzymes. Oxythiamine has been used to validate thiamine utilization as an anti-malarial … haveriplats bermudatriangelnWebThiamine uptake transmembrane transporter activity Specific Function High-affinity transporter for the intake of thiamine. Pfam Domain Function. Folate_carrier ; Transmembrane Regions 29-46 73-91 100-118 129-149 166-185 192-208 286-310 338-354 364-380 387-409 420-443 456-479 Cellular Location Membrane Gene sequence havilah residencialWebThiamine transporter. Members of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI … havilah hawkinsWeb19 Apr 2012 · In affected members of an Iranian family with thiamine-responsive megaloblastic anemia syndrome (TRMA; 249270 ), Diaz et al. (1999) identified a 2-bp … haverkamp bau halternWebDescription. Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia 1 2 3 4. have you had dinner yet meaning in punjabi