Web10. mar 2010 · The history of the development of these drugs is well known and documented. suramin, pentamidine and melarsoprol were developed in the first half of … Web4. jan 2024 · Pentamidine is a medication used in the management and treatment of Pneumocystis pneumonia, leishmaniasis, and trypanosomiasis. It is in the anti-infective …
Pentamidine - an overview ScienceDirect Topics
Web6. aug 2014 · History of clinically significant hypoglycaemia, with fasting blood glucose < 3 mmol/L within 3 months prior to signature of ICF; ... Previous use of pentamidine with treatment discontinuation of less than 6 months prior to signature of ICF; Any of the following conditions: Ongoing clinically significant cardiac dysrhythmias such as atrial ... WebPentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two ... tiffany \u0026 co mission statement
[Human african trypanosomiasis: A history of its therapies and …
WebPentamidine (Fig. 5.93) is an aromatic diamidine that besides its antiprotozooal activity is also effective against the fungus Pneumocystis carinii.The exact mechanism of action of … Web28. máj 2008 · Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine … Pentamidine was first used to treat African trypanosomiasis in 1937 and leishmaniasis in 1940 before it was registered as pentamidine mesylate in 1950. Its efficacy against Pneumocystis jirovecii was demonstrated in 1987, following its re-emergence on the drug market in 1984 in the current … Zobraziť viac Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with Zobraziť viac • Treatment of PCP caused by Pneumocystis jirovecii • Prevention of PCP in adults with HIV who have one or both of the following: • Treatment of leishmaniasis • Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Zobraziť viac The additional or sequential use of other nephrotoxic drugs like aminoglycosides, amphotericin B, capreomycin, colistin, polymyxin B, vancomycin, foscarnet, or cisplatin should be closely monitored, or whenever possible completely avoided. Zobraziť viac Absorption: Pentamidine is completely absorbed when given intravenously or intramuscularly. When inhaled through a nebulizer, … Zobraziť viac • Patients with a history of anaphylaxis or hypersensitivity to pentamidine isethionate Zobraziť viac Common • Burning pain, dryness, or sensation of lump in throat • Chest pain • Coughing • difficulty in breathing Zobraziť viac The mechanism seems to vary with different organisms and is not well understood. However, pentamidine is suspected to work through various methods of interference of critical functions in DNA, RNA, phospholipid and protein … Zobraziť viac tiffany \u0026 co. mens diamond wedding bands