Splet26. maj 2024 · Investigation of basic chronic inflammatory mechanisms and development of new therapeutics targeting the respiratory tract requires appropriate testing systems, including those to monitor long- persistence. Human precision-cut lung slices (PCLS) have been demonstrated to mimic the human respiratory tract and have potential of an … Splet12. maj 2024 · •将透视剪裁层封装到通用的NN层中，称为pcl，它可以集成到现有的深度学习框架。 现有技术 ： 对于传统CNN：对图像通常采用局部处理的方法，而传统相机投影的透视效果会因不同图像的全局位置不同而不同（一般图像之间以图像中心点为中心） 本文提出PCLS:透视裁剪层，基于相机的几何形状，对感兴趣区域（ROI）进行透视裁剪，是神经 …
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Splet04. dec. 2024 · Human PCLS have been shown to produce bile acids and to be sensitive to drug-induced cholestasis . Their capability of taking up bile acids or to express genes … Splet19. jul. 2024 · Additional challenges associated with the use of PCLS include maintaining the slices ex vivo. Typically, PCLS are submerged in culture medium in multi-well plates at 37 °C, 5% CO 2 and 95–100% air humidity under tissue culture conditions, and medium is changed daily (examples of culture conditions shown in Table 1).The culture medium has … soweto marathon start list
PCLS for the optimization of new drugs - Fraunhofer ITEM
Splet10. jan. 2024 · PCLS were originally used in toxicology studies; however, the advantages of the model have allowed it to be applied to wider applications. The major advantage of the model is that it maintains the 3-dimensional (3D) architecture of the lung, which is lost in in vitro cultures of cells isolated from the lung. SpletIn the PCLS, at Time 1, we set out to measure adaptive behavior in three primary domains that we viewed as important criteria of success for school-aged children: academic achievement, peer relations, and conduct (e.g., compliance or following rules versus aggressive or disruptive behavior). These domains had a long history of conceptual and ... SpletContributions of the Project Competence Longitudinal Study (PCLS) to resilience science and developmental psychopathology are highlighted in this article. Initiated by Norman Garmezy, the PCLS contributed models, measures, and methods, as well as working definitions of concepts like competence, deve … team lewis france