WebSep 19, 2024 · その結果、Rosa26にあるlox配列に挟まれたSTOP配列がCreERT2の組換えにより除かれ、後ろにあるtdTomatoが発現可能となり、p16陽性細胞は赤くラベルされる。またジフテリア毒素(DT)を加えることで赤くラベルされたp16陽性細胞を特異的に除くことも可能である。 WebSingle-cell RNA-seq analyses of various tissues from early middle-aged p16-CreERT2-tdTomato mice reveal that p16 high cells exhibit heterogenous senescence-associated phenotypes, while elimination of p16 high cells ameliorates steatosis and inflammation in a NASH model. There were a variety of senescent cells in the kidney, lung, liver, heart ...

図1 p16-CreERT2-tdTomatoマウスの仕組み (image) - EurekAlert!

Web論文タイトル：Generation of a p16 reporter mouse and its use to characterize and target p16hight cells in vivo 著者：Satotaka Omori#, Teh-Wei Wang#, Yoshikazu Johmura*, … Web研究人员开发了一个p16-Cre ERT2-tdTomato小鼠模型，其能够在单细胞水平上分析p16 high 细胞的体内特征。 研究人员发现在所有器官中都可检测到tdTomato阳性p16 high 细胞， … asia kosher restaurant menu

Tamoxifen诱导Cre-ERT2小鼠 cre小鼠品系介绍 南模生物

WebSep 28, 2024 · The research team generate a p16-Cre ERT2 - tdTomato mouse model to uncover the in vivo dynamics and properties of p16high cells. Single-cell RNA-seq … WebSep 18, 2024 · Omori et al. generate a p16-CreERT2-tdTomato mouse model to uncover the in vivo dynamics and properties of p16high cells. Single-cell RNA-seq analyses of various tissues from early middle-aged p16-CreERT2-tdTomato mice reveal that p16high cells exhibit heterogenous senescence-associated phenotypes, while elimination of p16high … Web(*1) p16-Cre ERT2 -tdTomato mouse model Mice inserting CreERT2 into the endogenous Ink4a locus with Rosa26-CAG-lsl-tdTomato. In this mouse model, p16 high cells are labelled with tdTomato (red fluorescence) in vivo by tamoxifen administration. asia kya