Organic anion transporter 2
WitrynaThe members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles … Witryna18 lut 2010 · Abstract. Human organic anion transporter 2 (hOat2 [SLC22A7]) is highly expressed in the human liver.Although localization, gene expression, substrate specificity and transport mechanisms of other human Oat isoforms such as human Oat1 (hOat1), human Oat3 (hOat3) and human Oat4 (hOat4) have been elucidated, information …
Organic anion transporter 2
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Witryna18 maj 2010 · Solute carrier organic anion transporter family member 5A1. Alternative names. Organic anion transporter polypeptide-related protein 4 (OATP-RP4; OATPRP4) Solute carrier family 21 member 15; Gene names. Name. SLCO5A1. Synonyms. OATP5A1, SLC21A15. Organism names. Organism. Homo sapiens (Human) Witryna1 mar 2012 · This study provides definitive evidence for the expression of Oat2 in the human kidney and is the first to demonstrate that OAT2, compared with OAT1, OAT3, or OCT2, has a preference for antiviral drugs mainly eliminated in the urine via active secretion. The organic anion transporters 1 and 3 (OAT1 and OAT3) and organic …
Witryna21 paź 2024 · Organic anion transporter 2 (OAT2 or SLC22A7) plays an important role in the hepatic uptake and renal secretion of several endogenous compounds and … Witryna2 lut 2024 · Definition. Organo-Anion-Transporter, kurz OATs, sind Membranproteine, die vorwiegend organische Anionen über Zellmembranen transportieren. Sie umfassen Proteine, die zur SLCO- und zur SLC22A-Superfamilie zählen. Erstere werden auch als "organic anion transporting polypeptides", kurz OATPs, bezeichnet.
Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer … Zobacz więcej Proteins of the OAT family catalyze the Na -independent facilitated transport of fairly large amphipathic organic anions (and less frequently neutral or cationic drugs), such as bromosulfobromophthalein, prostaglandins, … Zobacz więcej The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the basolateral membrane of hepatocytes, transporting compounds into the hepatocyte for Zobacz więcej The various paralogues in a mammal have differing but overlapping substrate specificities and tissue distributions as summarized by Hagenbuch and Meier. These authors also provide a phylogenetic tree of the mammalian members of the family, … Zobacz więcej The table below shows the 11 known human OATPs. Note: Human OATPs are designated with capital letters, animal Oatps are designated with lower class letters. The … Zobacz więcej OATPs are present in many animals, including fruit flies, zebrafish, dogs, cows, rats, mice, monkeys and horses. OATPs are not present in bacteria, indicating their evolution from … Zobacz więcej WitrynaGeneral References. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. …
WitrynaThe organic anion transporters 1 (OAT1) and 3 (OAT3) take up acidic xenobiotics from the pericapillary space in exchange for alpha-ketoglutarate and other dicarboxylic acids (Burckhardt and Wolff, 2000). Similarly, the organic cation transporters 1 (OCT1), 2 (OCT2), and 3 (OCT3) are present in the basolateral membrane of the proximal and …
Witryna5 mar 2024 · Using stably transfected HEK293 cells, both enantiomers were found to be substrates of organic anion transporter (OAT)2 with a Michaelis-Menten constant ( … litchfield heraldWitrynaNational Center for Biotechnology Information litchfield hills bike rideWitrynaNa + -independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in … imperial health provider numberWitryna3. Enomoto, A., et al., Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther, 2002. 301(3): p. 797-802. 4. Cheng, Y., et al., Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. litchfield high school teacher arrestedWitryna29 mar 2024 · Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). The role of OAT2-mediated hepatic uptake in determining … imperial health provider searchWitryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity … litchfield hills greenprint mapWitryna Aims imperial health referral form