Inhibition of argininosuccinate lyase
Webb21 mars 2013 · The metabolomics analysis revealed that the urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency. Argininosuccinate was found to be produced from arginine and fumarate by the reverse activity of the urea cycle enzyme argininosuccinate lyase (ASL), making these cells … WebbThe percentage of urea-dependent inhibition of argininosuccinate lyase detected at a single concentra- tion of the substrate (1 mM citrulline) and in the presence of …
Inhibition of argininosuccinate lyase
Did you know?
Webb19 aug. 1997 · Argininosuccinate lyase (ASL; EC 4.3.2.1) participates in the urea cycle, the major pathway for the detoxification of ammonia, where it catalyzes the reversible … WebbArgininosuccinate synthase (ASS) combines citrulline with aspartate through an energy-consuming process. ASS is inhibited by branched-chain amino acids, alanine and lysine [1]. It is cytosolic, with highest expression in the liver, renal proximal tubules, and testis, but also has low expression in other tissues [48,50].
Webb15 juli 2024 · Given that cells can synthesize arginine from citrulline and aspartate via argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL), arginine is considered as a non-essential amino acid ( Chen et al., 2024 ). Thus, arginine depletion may be a promising therapeutic strategy for cancer management. FIGURE 1. Webb1 sep. 2024 · Argininosuccinate lyase (ASL) plays an important role in the hepatic urea cycle, and can catalyze the reversible reaction of argininosuccinate to arginine and fumarate. However, the function of ASL in hepatocellular carcinoma (HCC) is …
Webb13 juni 2005 · This compound belongs to the class of organic compounds known as aspartic acid and derivatives. These are compounds containing an aspartic acid or a … WebbIn our previous study, we observed that blocking argininosuccinate lyase (ASL) attenuates tumor progression in liver cancer. However, ... Furthermore, autophagy was observed in the cells expressing ASL shRNA, and inhibition of autophagy reduced cell growth, indicating that autophagy played a cell survival role in the ASL knockdown cells.
Webb30 mars 2024 · In the liver, ASS1 produces argininosuccinate from citrulline and aspartate. Outside the liver, ASS1 and its subsequent urea cycle enzyme argininosuccinate lyase regulate the citrulline-arginine cycle, both of which supply arginine and its downstream metabolites, including polyamines, nitric oxide, and proline, …
Webb1 jan. 2011 · Argininosuccinate synthase 1 (ASS1) is a key rate-limiting enzyme in the production of arginine, urea and nitric oxide. 10 The ASS1 gene, located on chromosome 9 and encoding arginine succinate ... men\u0027s shavers electric rechargeableWebb6 nov. 2013 · Degradation of arginine may be used to inhibit liver tumors with low argininosuccinate synthetase (ASS) expression. In this report, we investigated an alternative therapeutic approach by targeting argininosuccinate lyase (ASL). ASL is transcriptionally induced by endoplasmic reticulum stress and is overexpressed in some … how much vit d daily for womenWebb22 maj 2024 · Argininosuccinate lyase (EC 4.3.2.1) is the final enzyme in arginine biosynthesis that catalyzes the conversion of argininosuccinate to L-arginine and … men\u0027s shaving cream for sensitive skinWebbinhibition study of argininosuccinate lyase and have established that the kinetic mechanism is random. MATERIALS AND METHODS Argininosuccinate lyase was … men\u0027s shaving cream brandsWebb7 nov. 2016 · Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. … men\u0027s shaving clubWebbArgininosuccinate lyase catalyzes the last step of arginine biosynthesis by converting argininosuccinate into l-arginine and fumarate, and is a key enzyme in arginine biosynthesis in all organisms (Puthan Veetilet al. 2012). This enzyme belongs to the aspartase/fumarase superfamily and its crystal how much vit d dailyWebb23 nov. 2024 · Five enzymes are required for ureagenesis: CPS-I, ornithine transcarbamylase, argininosuccinate synthase, argininosuccinate lyase, and arginase. The urea cycle is also regulated by NAG, an essential cofactor necessary for the function of CPS-I. NAG is produced in the mitochondrial matrix from glutamate and acetyl … how much vit d a day uk