Hsf2bp brca2
Web13 feb. 2024 · We map the MEILB2-binding domain within BRCA2 that is distinct from the canonical DNA-binding domain but is sufficient to localize to meiotic DSBs in a MEILB2 … WebARTICLE BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination Rania Ghouil1,10, Simona Miron1,10, Lieke Koornneef 2,10, Jasper Veerman 3, Maarten W. Paul 3, Marie-Hélène Le Du1, Esther Sleddens-Linkels4, Sari E. van Rossum-Fikkert3,5, Yvette van Loon3, Natalia Felipe-Medina6, Alberto M. …
Hsf2bp brca2
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WebBRCA2 is a key homologous recombination mediator in vertebrates. Brandsma et al. show that it directly interacts with a testis-expressed protein, HSF2BP, and that male mice … Web21 mrt. 2024 · HSF2BP. heat shock transcription factor 2 binding protein. Gene ID: 11077, updated on 21-Mar-2024. Gene type: protein coding. Also known as: POF19; MEILB2. …
WebHSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis Graphical Abstract Highlights dHSF2BP forms a direct evolutionarily conserved interaction with BRCA2 dLossofHSF2BPdisruptsmeiotichomologousrecombination in spermatogenesis dIn … Web26 aug. 2024 · Hsf2bp S167L/S167L females show reduced fertility with smaller litter sizes. To obtain mechanistic insights, we identified C19ORF57/BRME1 as a strong interactor …
WebLoss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BRCA2 to meiotic HR sites, by solving the crystal structure of the BRCA2 fragment in complex with dimeric armadillo domain (ARM) of HSF2BP and disrupting this interaction in a mouse model. Web5 mrt. 2024 · BRCA2/HSF2BP complex associated protein) as a key component of the meiotic recombination machinery. Our studies show that a single substitution (S167L) in HSF2BP leads to a reduction in the loading of both MIDAP and HSF2BP at the recombination nodules. Furthermore, our results suggest that meiotic progression …
Web13 feb. 2024 · Here we identify a meiotic localizer of BRCA2, MEILB2/HSF2BP, that localizes to the site of meiotic DSBs in mice. Disruption of Meilb2 abolishes the …
Web1 jun. 2024 · HSF2BP contains an N-terminal α-helical oligomerisation domain and a C-terminal domain predicted to adopt an Armadillo fold 16, 17,25 . We mapped the … lawhon and associates columbus ohioWeb13 feb. 2024 · Here we identify a meiotic localizer of BRCA2, MEILB2/HSF2BP, that localizes to the site of meiotic DSBs in mice. Disruption of Meilb2 abolishes the localization of RAD51 and DMC1 recombinases in spermatocytes, leading to errors in DSB repair and male sterility. MEILB2 directly binds to BRCA2 and regulates its association to meiotic … lawhon associatesWebWe identify HSF2BP, a protein previously described as testis specific and not characterized functionally, as an interactor of BRCA2 in mouse embryonic stem cells, where the 2 proteins form a constitutive complex. HSF2BP is transcribed in all cultured human cancer ... [more] Cell Rep Dec. 25, 2024; 27 (13);3790-3798.e7 [ Pubmed: 31242413] Throughput lawhon arielWeb25 jun. 2024 · HSF2BP Is a Member of the BRCA Complex in mESCs We previously described efficient immunoprecipitation of BRCA2-GFP and most of the known BRCA2 … lawhon body shopWeb26 mei 2024 · Although it has been proposed that MEILB2/HSF2BP-BRCA2 interaction plays a crucial role in the recruitment of RAD51 and DMC1 onto ssDNA, the exact mechanisms for how the MEILB2/HSF2BP-BRCA2 complex acts for ssDNA processing remain elusive ( Zhang et al., 2024 ). kain ramsay life coachWebHSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Inger Brandsma, Koichi Sato, Sari E van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H W Dekkers, Karel Bezstarosti, ... kainrath hollabrunnWeb暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 lawhon construction