WebIn 2006, Dr. Sharma designed and conducted the first neoadjuvant (pre-surgical) trial, also known as a window-of-opportunity trial, with immune checkpoint therapy (anti-CTLA-4, ipilimumab), which allowed her to establish safety of the neoadjuvant approach for immune checkpoint therapy as well as provide tumor tissues for translational research ... WebFeb 12, 2024 · Regulation of the canonical GPX4-regulated pathway is as follows: ① Directly inhibit GPX4 by upregulating miR-324-3p or downregulating AR and KIF20A. ② Inhibit GSH biosynthesis by ent-kaurane diterpenoids. ③ Inhibit cystine uptake by erastin and sorafenib or upregulating miR-375 and ATF3.
Induction and application of ferroptosis in cancer therapy
WebNov 9, 2024 · These findings support targeting GPX4 as a therapeutic strategy to prevent acquired drug resistance. We sought to identify therapeutically exploitable vulnerabilities in an experimental model of minimal residual disease, drug-tolerant persister cells. WebAug 3, 2024 · In this review, we summarize the regulation of the System X c − /GSH/GPX4 axis, a major antioxidant system in ferroptosis, and its potential role in drug-resistant solid tumors therapy, and also conclude with a summary of drugs, compounds and nanoparticles targeting this axis that have been studied in recent years. custom wiring harness
A GPX4-dependent cancer cell state underlies the clear-cell ... - Nature
WebJun 19, 2024 · Glutathione peroxidase 4 (GPX4), a selenocysteine enzyme that utilizes glutathione to reduce toxic lipid peroxides into non-toxic lipid alcohols, is critical for the protection against lipid peroxide-mediated damage and ferroptosis induction [ 11 ]. WebJan 21, 2011 · GPX4 volume density is increased from 0.0018 ± 0.0002 in controls (n = 11) to 0.0038 ± 0.0007 in PD (n = 12) (P = 0.0192), indicating that GPX4 is either … WebMar 21, 2024 · GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include Spondylometaphyseal Dysplasia, Sedaghatian Type and … custom wiring harness for semi truck